The story follows Joe, (Cage), a down-on-his-luck truck driver haunted by the memory of his deceased wife and child. He meets Julie (Potente), a spiritually gifted woman who enlists Joe in a desperate effort to find the lost soul of her comatose daughter, Billie (Mitchell). But the spirit of Joe's dead wife Mary proves stronger, possessing the young woman's body and determined to settle her unfinished business with the living.
Jennifer and Ryan are students at UC Berkeley, acquaintances off and on since early adolescence. She's quick, witty, ironic, literary, and independent; he's deliberate, literal, serious, studying structural engineering, always working on a plan. They take walks, they console each other over break-ups, he shares his plans. She's headed for Italy after graduation. Then, to their equal surprise, they spend a night together. Her response is to skitter away from continued intimacy and want to stay friends; he's hurt by her response, so he withdraws. Can it all get sorted out before she leaves town?